The most substantial support comes from investigations reporting successful back pain relief following peri-articular joint injections. Since then, the so-called “facetogenic back pain” has become a widely accepted diagnosis, though still controversial in the literature. Lumbar spinal facet joints were first suggested in the medical literature as a source of low back and lower extremity pain in 1941. One of the leading anatomical structures involved in the pathogenesis of low back pain are the facet joints. A whole variety of pathological processes are responsible for low back pain. Low back pain (LBP) poses an economic burden to society, mainly in terms of the large number of workdays lost by a small percentage of patients who develop chronic forms of low back pain. Conclusions: Our observational data indicate that facet joint syndrome patients treated with unmodified adipose tissue-derived regenerative cells experience improved the quality of life in the long term. Results: Every patient reported improved VAS pain at any follow-up (1 week, 1 year, and 5 years) with ADRCs compared to the baseline. Follow-up examinations were performed at 1 week, 1 year, and 5 years. The cells were then injected under fluoroscopic control in the periarticular fat. To recover stem cells from adipose tissue, we use the CE-certified Transpose RT™ system from InGeneron GmbH. An amount of 50–100 cc of fat was harvested. Methods: We report long-term results of 37 patients (age 31–78 years, mean 62.5) suffering from “Facet Joint Syndrome” The pathology was confirmed by clinical, radiological examinations and fluoroscopically guided test injections. ADRCs can be obtained from a small amount of fatty tissue derived from the patient’s abdominal fat. These regenerative cells can differentiate into various tissues and exhibit a strong anti-inflammatory potential. Advances in regenerative medicine have shown that autologous unmodified adipose tissue-derived regenerative cells (ADRC) provide several beneficial effects. Background: Chronic back pain due to facet joint syndrome is a common and debilitating condition.
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